Therapeutical Class：5-aminosalicylic acid derivative and sulfapyridine, inhibition of prostaglandin synthesis

Indication：Crohn’s disease, rheumatoid arthritis, ulcerative colitis.

Administraton：PO.

Adults:

Ulcerative colitis: Initial, 1 g 3-4 times/day, 2g/day maintenance in divided doses. Rheumatoid arthritis: 0.5-1 g/day, increase weekly to maintenance dose of 2 g/day in 2 divided doses.

Children:

Ulcerative colitis: Initial, 40-60 mg/kg/day in 3-6 divided doses;

maintenance doses, 20-30 mg/kg/day in 4 divided doses.

Rheumatoid arthritis: 30-50 mg/kg/day in 2 divided doses.

Renal impairment: Ccr 15-30 ml/min, twice daily;

Ccr <10 ml/min, once daily.

Adverse Effect：Nausea, anorexia (>10%), abdominal pain, headache (33%), dizziness, diarrhea (33%), tinnitus, peripheral neuropathy, photosensitivity, erythema multiforme, pruritus, reversible oligospermia (33%), rash (>10%), agranulocytosis, thrombocytopenia, leucopenia, crystalluria, hematuria and drug fever, chills.

Contraindication：Hypersensitivity to sulfonamides or salicylates, pregnancy at term & during lactation, children < 2 yrs of age, porphyria, intestinal or urinary obstruction.

Pregnancy Risk：B

Supply：Salazine XE “Salazine” EC Tab 500mg（撒樂腸溶錠 信東）＜11033＞