Therapeutical Class：Cephamycins, inhibit cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis

Indication：G(+): not for Enterococci & MRSA; G(-): E. Coli, H. influenzae, Klebsiella, Proteus, Enterobacter, Acinetobacter; anaerobes: not for Clostridium difficile.

Administraton：IV or IM.

Adults: 1-2 g q6-8 h, max.12 g/day.

Renal impairment: Ccr 30-50 ml/min, 1-2 g q 8-12 h;

Ccr 10-29 ml/min, 1-2 g q12-24h;

Ccr 5-9 ml/min, 0.5-1 g q12-24hr;

Ccr < 5 ml/min, 0.5-1 g q24-48h.

Children: >3 months, 80-160 mg/kg/day divided in q4-6h; max.12 g/day.

Adverse Effect：Diarrhea (1-10%), injection site pain, thrombophlebitis, nausea, vomiting, anaphylaxis, interstitial nephritis, elevated, ALT, AST, angioedema, neutropenia, thrombocytopenia, anemia

Pregnancy Risk：BSupply：Cexitin XE “Cexitin”  Injection 1000mg(速新 瑞安) ＜10902＞