Therapeutical Class：Aminoglycosides, inhibit protein synthesis by binding to 30S ribosomal subunits

Indication：G(-): E.coli, H. influenzae, Klebsiella, Enterobacter, Pseudomonas, Proteus, Providencia, Serratia; G(+): Staphylococci.

Administraton：IM or IV.

Adults: Conventional: 1-2.5 mg/kg/dose q8-12h  

Once-daily: 4-7 mg/kg/dose once daily.

Children: 2-2.5 mg/kg/dose q8h.

Renal impairment; Ccr >60 ml/min, q8h;

Ccr 40-60 ml/min, q12h;

Ccr 20-40 ml/min, qd;

Ccr <20 ml/min, loading dose, then monitor levels.

Adverse Effect：Renal dysfunction (>10%), hearing abnormalities(>10%), allergy (rash, etc. <1%), edema (1-10%), neuromuscular blockade.

Pregnancy Risk：DSupply：Gentamicin XE “Gentamicin”  Sulfate Inj 80mg/2ml（見大黴素注射液 生達）＜10866＞