Therapeutical Class：Natural penicillins, inhibit cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis

Indication：G(+): except β-lactamase producing Staphylococci; G(-): Meningococcus, Gonococcus; some anaerobes and spirochetes.

Administraton：IV or IM, IM is painful.

Adults: IV 2-30 million units/day q4-6h.

Erysipelas: IV 1-2 million units q4-6h.

Leptospirosis: 1.5 million units q6h for 7 days.

Listeria: IV 15-20 million units/day q4-6h for 2 wks (meningitis) or 4 wks (endocarditis).

Neurosyphilis: IV 18-24 million units/day q4h (or by continuous infusion) for 10-14 days.

Streptococcal pneumonia: IV 2-3 million units q4h.

Children: 100,000-400,000 units/kg/day in 4-6 divided doses (Max dose: 24 million units/day).

Renal impairment: Ccr <10 ml/min/1.73 m2, full loading dose followed half of loading dose q8-10 hr.

Adverse Effect：Hemolytic anemia, eosinophilia, leukopenia, neutropenia, granulocytopenia, agranulocytosis, diarrhea, pain at injection site, myoclonus, convulsion, fluid overload, hypersensitivity.

Pregnancy Risk：BSupply：Penicillin G Sod Inj 3 Mega Unit（芐基青黴素鈉注射液用粉 永豐）＜02264＞