Therapeutical Class：Tetracycline derivative, inhibits bacterial protein synthesis by binding to the 30s subunit on the ribosome and inhibits binding of the aminoacyl-t-RNA molecules

Indication：G(+), G(-), anaerobes (including Clostridia, but not for B. fragilis), Chlamydia, Mycoplasma pneumoniae, Rickettsiae.

Administraton：

IV.

Children >8 years: Initial 4 mg/kg, followed by 2 mg/kg q12h (max. 400 mg/day). Adults: Initial 200 mg, followed by 100 mg q12h (max. 400 mg/day).

PO.

Adults: 200 mg initially, then 100 mg q12h.

Children (>8 yrs): 4 mg/kg initially, followed by 2 mg/kg q12h.

Adverse Effect：Gl disturbance (dose related), motting and discoloration of teeth, increased BUN and acidosis in pre-existing renal impairment, autoimmune hepatitis, fatal hepatic failure, vestibular symptoms (vertigo, ataxia, nausea, vomiting), lupus-like syndrome.

Pregnancy Risk：D

Supply：Cyclin XE “Cyclin” Cap 100mg（賽靈膠囊 瑞安）＜10523＞