Therapeutical Class：Cephamycins, inhibit cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis, contain N-methylthiotetrazole (NMTT) side chain.

Indication：G(+): not for Enterococci and Listeria, G(-): not for Pseudomonas, Enterobacter, Serratia; anaerobes.

Administraton：IV

Adults: 2 g q6-12h;

Severe or life-threatening infections: 8 g/day.

Renal impairment: Ccr 50-90 ml/min, 1-2 g q12h;

 Ccr 30-49 ml/min, 1-2 g q16h;

Ccr 11-29 ml/min, 1-2 g qd;

Ccr <10 ml/min, 1-2 g qod.

Adverse Effect：Allergy (rash, etc.1-10%), diarrhea (1-10%), nausea, vomiting, shock, hypersensitivity, leukopenia, thrombocytopenia, PT prolongation, elevated BUN, ALT, AST and ALK-P.

Pregnancy Risk：BSupply：Cetazone XE “Cetazone”  Injection 1gm (喜達隆注射劑  信東) ＜10733＞