Therapeutical Class：Aminopenicillins, inhibit cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis

Indication：G(+): penicillin sensitive Staphylococci, Streptococci, Enterococci; G(-): E.coli, H. influenzae, P. mirabilis, Shigella, Salmonella.

Administraton：

Adults: PO, IV or IM 250-500 mg q6h.

Sepsis/meningitis: IV or IM 150-250 mg/kg/day in 6-8 divided doses.

Children: PO 50-100 mg/kg/day, max 2-4 g/day in 4 divided doses; IM or IV 100-400 mg/kg/day, max 12 g/day in 4 divided doses.

Mild to moderate infection:

Oral: 50-100 mg/kg/day, max 2-4 g/day in 4 divided doses;

IM or IV 100-150 mg/kg/day, max 2-4 g/day in 4 divided doses.

Severe infection: IM or IV 200-400 mg/kg/day, max 6-12 g/day in 4 divided doses. Renal impairment: Ccr 10-50 ml/min, q6-12h;

Ccr <10 ml/min, q12-24h;

Hemodialysis: administer dose after dialysis; PD: 250 mg q12h.

Adverse Effect：Nausea, vomiting, diarrhea, abdominal or stomach cramps, nonallergic ampicillin rash, penicillin encephalopathy, seizure, lymphocytic leukemia.

Pregnancy Risk：B

Supply：Ampicillin XE “Ampicillin”  Cap 500mg（安比西林膠囊 榮民）＜00083＞Ampolin XE “Ampolin”  Inj 500mg（安博黴素注射劑 永豐）<10290>